๐งฌ Ipamorelin Peptide
Overview
Ipamorelin is a synthetic growth hormone secretagogue and ghrelin receptor agonist that stimulates the natural release of growth hormone (GH) from the pituitary gland. Known for being one of the safest and most selective GHRPs (growth hormone-releasing peptides), Ipamorelin promotes muscle growth, fat loss, recovery, and anti-aging benefits without significant side effects like hunger spikes or cortisol elevation.
๐ Category
Peptide Secretagogue for GH Stimulation, Recovery, and Anti-Aging
๐ฌ Molecular Profile
Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NHโ
Molecular Weight: ~711.86 g/mol
Molecular Formula: C38H49N9O5
Structure: Pentapeptide that selectively binds to ghrelin (GHS-R1a) receptors
๐ What Is Ipamorelin?
Name: Ipamorelin
Type: Synthetic peptide, GH secretagogue
Function: Triggers the pituitary to release natural pulses of growth hormone
Use: Widely used in fat loss, muscle recovery, anti-aging, and GH optimization protocols
๐งช Mechanism of Action
Ipamorelin mimics the activity of ghrelin, the "hunger hormone", but without appetite stimulation. It acts by:
Binding to ghrelin receptors (GHS-R1a) in the pituitary and hypothalamus
Stimulating pulsatile release of GH, leading to increases in IGF-1
Avoiding elevation of cortisol, prolactin, or ACTH (unlike older GHRPs)
Mimicking natural hormonal rhythms, making it ideal for daily or post-workout use
๐ฉบ Most Common Uses
โ๏ธ Potential Benefits
Muscle, Fat, and Physique
Stimulates muscle hypertrophy and strength
Improves fat-burning, particularly in abdominal region
Helps retain lean mass during calorie restriction
Recovery & Wellness
Supports joint, tendon, and ligament repair
Accelerates post-exercise recovery
Enhances deep (slow-wave) sleep
Hormonal & Cognitive Support
Elevates IGF-1 levels naturally
Improves mental clarity, energy, and mood
No suppression of natural GH production
๐ Administration & Dosage
Delivery Forms
Injectable โ subcutaneous injection, often taken in cycles
Typical Research Dosages
๐ Scientific Research
Ipamorelin has been studied in both animals and humans for its selective GH-releasing profile:
GH and IGF-1 Elevation: Clinical trials showed significant increases in GH without affecting cortisol or prolactin
Well Tolerated: Demonstrated a favorable safety profile over both short and long durations
Synergy: When paired with CJC-1295 (no DAC), mimics youthful GH patterns more effectively than either alone
A 2005 study confirmed that Ipamorelin elevated GH levels significantly with no increase in ACTH or cortisol, making it ideal for long-term use.
โ ๏ธ Safety & Side Effects
Commonly Reported
Mild water retention
Temporary tingling or flushing after injection
Rare: headaches or slight fatigue
Toxicology
No significant toxic effects noted in trials
No prolactin or cortisol elevation, unlike older GHRPs like GHRP-6
๐ Legal & Regulatory Status
FDA Status: Not approved for medical use
Classification: Research peptide
Availability: Sold for research purposes and used in functional medicine clinics
โ FAQ
What makes Ipamorelin safer than GHRP-6 or GHRP-2?
Ipamorelin doesnโt elevate cortisol or prolactin, and doesnโt stimulate appetite, making it cleaner and better tolerated.
Can it be stacked with other peptides?
Yes โ best paired with CJC-1295 (with or without DAC), BPC-157, or TB-500 for performance or recovery stacks.
How quickly do effects appear?
Users often report better sleep, recovery, and leaner physique within 4โ6 weeks of consistent use.
Do I need to cycle it?
Not required, but many users follow an 8โ12 week cycle, with breaks or adjustments for long-term use.
๐ Summary
Ipamorelin is one of the safest and most effective peptides for stimulating natural GH release. Its clean profile, lack of significant side effects, and powerful anabolic and anti-aging properties make it a cornerstone in modern peptide therapy. Whether for muscle gain, fat loss, or restorative recovery, Ipamorelin stands out as a go-to peptide for health optimization.
Disclaimer: This guide is for educational use only and not medical advice.
Sourcing
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USA & Canada
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