🧬 CJC-1295 without DAC (MOD-GRF 1-29) Peptide
Overview
CJC-1295 without DAC, also known as MOD-GRF 1-29, is a short-acting analog of growth hormone-releasing hormone (GHRH). It stimulates the anterior pituitary to release natural growth hormone (GH) in a pulsatile fashion, mimicking the body's natural GH secretion rhythm. This version does not include the Drug Affinity Complex (DAC), resulting in a shorter half-life, but greater control over timing and synergy when stacked with peptides like Ipamorelin.
📂 Category
Peptide Hormone Analog for Pulsatile GH Stimulation
🔬 Molecular Profile
Sequence: Modified GRF (1-29)
Molecular Weight: ~3357.88 g/mol
Molecular Formula: C152H252N44O42S
Structure: Modified version of the first 29 amino acids of natural GHRH, with substitutions to enhance stability
📌 What Is CJC-1295 without DAC?
Name: CJC-1295 (No DAC), also called MOD-GRF 1-29
Type: Short-acting GHRH analog
Function: Stimulates short bursts of GH release, mimicking the body’s natural rhythm
Use: Popular in performance, fat loss, and anti-aging applications; often stacked with GHRPs
🧪 Mechanism of Action
CJC-1295 without DAC works by directly signaling the pituitary gland to release GH:
Short Half-Life: ~30 minutes; designed for rapid, pulsed GH release
Pulsatile Secretion: Mimics physiological GH spikes, which are more natural and less likely to cause desensitization
Synergy with GHRPs: When combined with Ipamorelin, GHRP-2, or GHRP-6, it creates a powerful GH pulse
Improved Bioavailability: Modified sequence (MOD-GRF 1-29) is more stable than original GRF 1-29
🩺 Most Common Uses
⚕️ Potential Benefits
Physique Enhancement
Promotes lean muscle development
Enhances fat-burning, especially abdominal fat
Increases vascularity and tone
Hormonal Support
Boosts natural GH and IGF-1 production
Avoids the suppression seen with synthetic HGH use
Tissue & Skin Repair
Stimulates collagen synthesis, improving skin elasticity
Accelerates injury recovery and reduces joint pain
💉 Administration & Dosage
Delivery Forms
Injectable – subcutaneous administration, often at bedtime or post-workout
Typical Research Dosages
📚 Scientific Research
Though direct human clinical data is limited, research and user data suggest significant benefits:
GH and IGF-1 Boost: Rapid spikes in GH when combined with GHRPs
Body Recomposition: Users report fat loss, improved energy, and better recovery
Safe Pulsatility: Mimics normal GH cycles, reducing risk of side effects seen with long-acting GH analogs
A 2005 study on GHRH analogs showed increased growth hormone release within minutes, with peak GH seen at ~30–45 minutes post-injection.
⚠️ Safety & Side Effects
Reported (Anecdotal)
Mild flushing or warmth after injection
Temporary tingling or lightheadedness
Rare: water retention or carpal tunnel-like symptoms if overused
Toxicology
Short-acting profile reduces risk of desensitization
Very low toxicity reported in research and clinical experience
📜 Legal & Regulatory Status
FDA Status: Not approved for medical use
Classification: Research peptide
Legal Use: Available for research or compounded prescription use
❓ FAQ
What’s the difference between CJC-1295 with and without DAC?
With DAC: Long-acting; weekly injection
Without DAC (MOD-GRF 1-29): Short-acting; mimics natural GH pulses; dosed daily or multiple times/day
Can it be used alone?
Yes – but best results occur when combined with a GHRP peptide like Ipamorelin or GHRP-2.
When should I dose it?
Best times: before bed (supports sleep and natural GH release) and post-workout (enhances recovery).
Is it better than HGH?
It’s not a replacement but a stimulator of your body’s own GH – safer, more physiological, and less suppressive.
🔍 Summary
CJC-1295 without DAC (MOD-GRF 1-29) is a short-acting GHRH analog that allows for precision control of growth hormone pulses, especially when stacked with GHRPs. It’s ideal for those seeking lean gains, fat loss, improved sleep, and anti-aging effects—all while avoiding long-term suppression seen with synthetic GH use.
Disclaimer: This content is for informational purposes only and does not constitute medical advice.
Sourcing
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