Overview
AOD-9604 (Advanced Obesity Drug) is a synthetic peptide fragment derived from the C-terminus of human growth hormone (HGH). Unlike full-length HGH, AOD-9604 was specifically developed to stimulate fat burning without affecting blood sugar or IGF-1 levels, making it a unique tool for fat loss, metabolic support, and obesity research. It has gained popularity for its ability to reduce stubborn body fat, particularly visceral and abdominal fat, while preserving lean muscle.
๐ Category
Peptide Fragment for Fat Loss and Metabolic Regulation
๐ฌ Molecular Profile
Sequence: Tyr-His-Ala-Arg-Leu-Gly-Phe-Ser-Pro-Ser
Molecular Formula: CโโHโโโNโโOโโSโ
Molecular Weight: ~1815.1 g/mol
Structure: Modified fragment of HGH (177โ191) โ a non-anabolic portion designed to promote lipolysis without GH-like side effects
๐ What Is AOD-9604?
Name: AOD-9604 (Advanced Obesity Drug)
Type: Synthetic peptide fragment of HGH
Function: Stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat formation)
Use: Designed for weight loss, fat-burning, and metabolic enhancement without HGHโs anabolic effects
๐งช Mechanism of Action
AOD-9604 selectively mimics the fat-reducing actions of human growth hormone without increasing IGF-1 or causing insulin resistance:
Activates ฮฒ3-adrenergic receptors โ Promotes fat breakdown (lipolysis)
Inhibits adipogenesis โ Reduces formation of new fat cells
No effect on blood glucose or insulin levels
No impact on muscle growth or IGF-1 โ purely metabolic, not anabolic
๐ฉบ Most Common Uses
โ๏ธ Potential Benefits
Body Composition
Reduces visceral and subcutaneous fat
Preserves lean muscle mass during calorie restriction
No water retention or bloat
Metabolic Health
Improves lipid profile and fat metabolism
Does not suppress or stimulate GH or IGF-1 pathways
Safe for use in metabolically sensitive individuals
Lifestyle Enhancement
Can be used alongside diet and exercise
Minimal to no side effects, making it a good option for long-term weight maintenance
๐ Administration & Dosage
Delivery Forms
Injectable (Subcutaneous) โ most common and effective
Oral (Capsule) and topical creams are available but may have reduced bioavailability
Typical Research Dosages
๐ Scientific Research
Clinical Trials: Tested in human trials for obesity treatment; shown to increase fat breakdown without altering blood sugar
Safety Studies: No adverse effects on glucose, IGF-1, or cortisol
Animal Models: Demonstrated strong lipolytic activity in obese rodent models
Human Results: Effective in reducing abdominal fat in adults and children without affecting lean mass
AOD-9604 was approved by Australiaโs TGA in 2013 as a listed compound for weight loss support.
โ ๏ธ Safety & Side Effects
Commonly Reported
Mild injection site redness or swelling
Very well-tolerated overall
No GH-related side effects (no growth, no joint pain, no glucose disruption)
Monitoring
No need for IGF-1, liver, or glucose monitoring unless stacking with other compounds
Ideal for individuals sensitive to hormonal therapies
๐ Legal & Regulatory Status
FDA Status (U.S.): Not approved for medical use
TGA Status (Australia): Approved as a listed medicine in 2013
Availability: Sold as a research peptide, compounded injectable, or fat-loss topical
Legal Use: Allowed in aesthetic clinics and functional medicine under physician guidance
โ FAQ
Is AOD-9604 the same as HGH?
No โ it is a fragment of HGH that only retains fat-burning properties, not the anabolic, growth-promoting ones.
Will it affect IGF-1 or insulin?
No โ studies confirm no impact on IGF-1 or blood glucose levels, making it safe for insulin-sensitive users.
Can I stack AOD-9604 with other peptides?
Yes โ commonly stacked with CJC-1295, Ipamorelin, Tesamorelin, or MK-677 in fat-loss protocols.
When will I see results?
Most users report visible fat reduction in 4โ6 weeks, with optimal results over 8โ12 weeks.
๐ Summary
AOD-9604 is a powerful, non-anabolic peptide fragment of HGH developed for fat reduction without hormone disruption. It provides a safe, non-invasive option for those seeking to shed stubborn body fat, especially visceral fat, without impacting blood sugar, IGF-1, or causing water retention. Ideal for weight loss, anti-aging, and lifestyle optimization programs.
Disclaimer: This content is for informational use only and does not constitute medical advice.
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