๐Ÿงฌ AOD-9604 Peptide

Overview

AOD-9604 (Advanced Obesity Drug) is a synthetic peptide fragment derived from the C-terminus of human growth hormone (HGH). Unlike full-length HGH, AOD-9604 was specifically developed to stimulate fat burning without affecting blood sugar or IGF-1 levels, making it a unique tool for fat loss, metabolic support, and obesity research. It has gained popularity for its ability to reduce stubborn body fat, particularly visceral and abdominal fat, while preserving lean muscle.

๐Ÿ“‚ Category

Peptide Fragment for Fat Loss and Metabolic Regulation

๐Ÿ”ฌ Molecular Profile

  • Sequence: Tyr-His-Ala-Arg-Leu-Gly-Phe-Ser-Pro-Ser

  • Molecular Formula: Cโ‚‡โ‚ˆHโ‚โ‚‚โ‚ƒNโ‚‚โ‚ƒOโ‚‚โ‚ƒSโ‚‚

  • Molecular Weight: ~1815.1 g/mol

  • Structure: Modified fragment of HGH (177โ€“191) โ€“ a non-anabolic portion designed to promote lipolysis without GH-like side effects

๐Ÿ“Œ What Is AOD-9604?

  • Name: AOD-9604 (Advanced Obesity Drug)

  • Type: Synthetic peptide fragment of HGH

  • Function: Stimulates lipolysis (fat breakdown) and inhibits lipogenesis (fat formation)

  • Use: Designed for weight loss, fat-burning, and metabolic enhancement without HGHโ€™s anabolic effects

๐Ÿงช Mechanism of Action

AOD-9604 selectively mimics the fat-reducing actions of human growth hormone without increasing IGF-1 or causing insulin resistance:

  • Activates ฮฒ3-adrenergic receptors โ†’ Promotes fat breakdown (lipolysis)

  • Inhibits adipogenesis โ†’ Reduces formation of new fat cells

  • No effect on blood glucose or insulin levels

  • No impact on muscle growth or IGF-1 โ†’ purely metabolic, not anabolic

๐Ÿฉบ Most Common Uses

โš•๏ธ Potential Benefits

Body Composition

  • Reduces visceral and subcutaneous fat

  • Preserves lean muscle mass during calorie restriction

  • No water retention or bloat

Metabolic Health

  • Improves lipid profile and fat metabolism

  • Does not suppress or stimulate GH or IGF-1 pathways

  • Safe for use in metabolically sensitive individuals

Lifestyle Enhancement

  • Can be used alongside diet and exercise

  • Minimal to no side effects, making it a good option for long-term weight maintenance

๐Ÿ’‰ Administration & Dosage

Delivery Forms

  • Injectable (Subcutaneous) โ€“ most common and effective

  • Oral (Capsule) and topical creams are available but may have reduced bioavailability

Typical Research Dosages

๐Ÿ“š Scientific Research

  • Clinical Trials: Tested in human trials for obesity treatment; shown to increase fat breakdown without altering blood sugar

  • Safety Studies: No adverse effects on glucose, IGF-1, or cortisol

  • Animal Models: Demonstrated strong lipolytic activity in obese rodent models

  • Human Results: Effective in reducing abdominal fat in adults and children without affecting lean mass

AOD-9604 was approved by Australiaโ€™s TGA in 2013 as a listed compound for weight loss support.

โš ๏ธ Safety & Side Effects

Commonly Reported

  • Mild injection site redness or swelling

  • Very well-tolerated overall

  • No GH-related side effects (no growth, no joint pain, no glucose disruption)

Monitoring

  • No need for IGF-1, liver, or glucose monitoring unless stacking with other compounds

  • Ideal for individuals sensitive to hormonal therapies

๐Ÿ“œ Legal & Regulatory Status

  • FDA Status (U.S.): Not approved for medical use

  • TGA Status (Australia): Approved as a listed medicine in 2013

  • Availability: Sold as a research peptide, compounded injectable, or fat-loss topical

  • Legal Use: Allowed in aesthetic clinics and functional medicine under physician guidance

โ“ FAQ

Is AOD-9604 the same as HGH?
No โ€“ it is a fragment of HGH that only retains fat-burning properties, not the anabolic, growth-promoting ones.

Will it affect IGF-1 or insulin?
No โ€“ studies confirm no impact on IGF-1 or blood glucose levels, making it safe for insulin-sensitive users.

Can I stack AOD-9604 with other peptides?
Yes โ€“ commonly stacked with CJC-1295, Ipamorelin, Tesamorelin, or MK-677 in fat-loss protocols.

When will I see results?
Most users report visible fat reduction in 4โ€“6 weeks, with optimal results over 8โ€“12 weeks.

๐Ÿ” Summary

AOD-9604 is a powerful, non-anabolic peptide fragment of HGH developed for fat reduction without hormone disruption. It provides a safe, non-invasive option for those seeking to shed stubborn body fat, especially visceral fat, without impacting blood sugar, IGF-1, or causing water retention. Ideal for weight loss, anti-aging, and lifestyle optimization programs.

Disclaimer: This content is for informational use only and does not constitute medical advice.

Sourcing

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