🧬 CJC-1295 (With DAC) Peptide
Overview
CJC-1295 with DAC is a synthetic growth hormone-releasing hormone (GHRH) analog designed to significantly increase growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels in the body. The “DAC” in its name stands for Drug Affinity Complex, which extends the peptide’s half-life and allows for long-lasting effects from a single weekly dose. CJC-1295 with DAC is widely used in anti-aging, muscle-building, and fat-loss protocols.
📂 Category
Peptide Hormone Analog with GH-Boosting and Anti-Aging Properties
🔬 Molecular Profile
Sequence: Modified GHRH(1-29) with Drug Affinity Complex (DAC)
Molecular Weight: ~3647.01 g/mol
Molecular Formula: C165H269N47O46
Structure: Tetrasubstituted analog of GHRH bound to a DAC to prolong its half-life
📌 What Is CJC-1295 with DAC?
Name: CJC-1295 with DAC
Type: Long-acting GHRH analog
Function: Stimulates the anterior pituitary to release growth hormone pulses over a prolonged period
Use: Enhances GH and IGF-1 production naturally, aiding recovery, fat loss, and muscle growth
🧪 Mechanism of Action
CJC-1295 with DAC mimics the body’s natural growth hormone-releasing hormone, with key enhancements:
GH Pulsatility: Stimulates pituitary to release GH in natural pulses, avoiding GH resistance
DAC Technology: The Drug Affinity Complex binds to albumin in the blood, extending its half-life to 1–2 weeks
Increased IGF-1: Elevated GH increases IGF-1 production in the liver, supporting anabolic and regenerative effects
Non-suppressive: Does not shut down natural GH production due to pulsatile stimulation
🩺 Most Common Uses
⚕️ Potential Benefits
Body Composition
Enhances lean muscle mass
Promotes fat oxidation and weight loss, especially visceral fat
Reduces catabolism and supports muscle retention
Skin, Joints, and Recovery
Improves skin elasticity and collagen density
Speeds up recovery from workouts and injuries
Supports joint health and repair
Hormonal Support
Elevates IGF-1 levels
Encourages natural GH rhythm without suppressing feedback loops
💉 Administration & Dosage
Delivery Forms
Injectable – subcutaneous injection
Typical Research Dosages
📚 Scientific Research
While human studies are limited, existing data and animal models support the benefits of CJC-1295 with DAC:
Increased GH and IGF-1: Sustained elevation of both over 7–14 days following a single dose
Body Composition Improvement: Reduced body fat and increased lean mass in multiple trials
Pituitary Activation: Maintains natural GH pulse patterns
Anti-Aging Support: Restoration of youthful hormone profiles in older adults
In a 2006 study, CJC-1295 increased GH levels by 2–10x baseline, and IGF-1 by 1.5–3x, with effects lasting up to 14 days.
⚠️ Safety & Side Effects
Reported (Anecdotal)
Redness or irritation at injection site
Mild water retention or bloating
Headache or fatigue (transient)
Vivid dreams or increased sleep depth
Toxicology
Non-toxic in clinical doses
Low risk of GH overstimulation compared to synthetic GH injections due to feedback regulation
📜 Legal & Regulatory Status
FDA Status: Not FDA-approved for medical use
Classification: Research chemical
Availability: Legal for research purposes; often used in peptide clinics under physician supervision
❓ FAQ
What's the difference between CJC-1295 with DAC and without DAC?
With DAC: Extended half-life (5–8 days); dosed weekly
Without DAC (MOD-GRF 1-29): Short half-life; requires multiple daily doses
Can it be stacked with other peptides?
Yes – commonly paired with Ipamorelin, GHRP-2, or GHRP-6 to enhance GH pulse synergy.
Is it a form of synthetic HGH?
No – it stimulates your own GH production, unlike synthetic GH which replaces it.
When will I see results?
Typically within 4–6 weeks; more dramatic changes often occur over 3–6 months of consistent use.
🔍 Summary
CJC-1295 with DAC is a powerful peptide designed for long-acting growth hormone stimulation, making it a favorite in anti-aging, body composition, and performance-enhancing protocols. By mimicking the body’s natural hormone signaling and using DAC to prolong its half-life, it delivers lasting results with fewer injections.
Disclaimer: This content is for educational purposes only and does not constitute medical advice.
Sourcing
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