🧬Clomiphene
Overview
Clomiphene citrate (commonly sold under the brand name Clomid) is a selective estrogen receptor modulator (SERM) widely used to treat infertility in women and to boost natural testosterone levels in men. It works by blocking estrogen receptors in the brain, which leads to increased production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)—key hormones that stimulate the gonads. Although effective, Clomiphene contains both the trans-isomer (Enclomiphene) and the cis-isomer (Zuclomiphene), the latter of which can cause unwanted estrogenic and emotional side effects.
📂 Category
Hormonal Modulators
Testosterone Restoration & Fertility Support
🔬 Molecular Profile
Chemical Name: (E)-2-(4-(2-Chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine citrate
Molecular Formula (citrate form): C₂₆H₂₈ClNO · C₆H₈O₇
Molecular Weight: ~598.1 g/mol
Type: Pure trans-isomer of Clomiphene (trans-Clomiphene)
Half-Life: ~10 hours (shorter than Clomid’s mixture)
📌 What Is Clomiphene?
Name: Clomiphene Citrate (Clomid)
Type: SERM (Selective Estrogen Receptor Modulator)
Function: Blocks estrogen receptors in the hypothalamus, increasing GnRH → LH/FSH → Testosterone/Sperm
Use: Originally developed for female fertility, now widely used for male testosterone restoration and PCT
🧪 Mechanism of Action
Clomiphene acts on the hypothalamic-pituitary-gonadal (HPG) axis by:
Blocking estrogen receptors at the hypothalamus
Preventing negative feedback from circulating estrogen
Increasing GnRH release → stimulates LH and FSH production
LH → stimulates testosterone production
FSH → supports spermatogenesis
🩺 Most Common Uses
⚕️ Potential Benefits
In Men
Increases total and free testosterone
Maintains or enhances fertility and testicular function
Improves libido, mood, and energy
Aids in recovery post-cycle (PCT)
Can be used alongside HCG, enclomiphene, or peptides
In Women
Stimulates ovulation in anovulatory cycles
Supports timed conception and IVF protocols
Physical & Mental Effects
Boosts energy, mood, and focus
May increase strength, lean muscle, and workout recovery
Reduces brain fog and supports executive function
💉 Administration & Dosage
Delivery Forms
Oral tablets – typically 25 or 50 mg doses
Typical Dosages (Men)
📚 Scientific Research
Male Hypogonadism: Clomiphene has been shown to restore testosterone levels to the normal range without causing suppression
Fertility: Increases sperm count and function, and is often used off-label for male infertility
Female Ovulation: Longstanding FDA-approved use for stimulating ovulation in women with PCOS or irregular cycles
Post-Cycle Recovery: Widely used in bodybuilding and HRT clinics for rebooting natural hormone production
⚠️ Safety & Side Effects
Common Side Effects
Visual disturbances (blurriness, floaters)
Mood swings, irritability, or anxiety (due to zuclomiphene)
Headaches or nausea
Increased estrogenic symptoms (gynecomastia, water retention)
Long-Term Risks
Desensitization of estrogen receptors
Potential for elevated SHBG or rebound estrogen
Prefer Enclomiphene for long-term or lower side effect use
📜 Legal & Regulatory Status
FDA Status: Approved for female fertility; widely used off-label in men
Prescription Only: Available as Clomid or generic clomiphene citrate
Sports: Banned by WADA for its effect on natural testosterone levels
❓ FAQ
Is Clomiphene the same as Enclomiphene?
Not exactly. Clomiphene is a 50/50 mix of two isomers—Enclomiphene (trans), which boosts testosterone, and Zuclomiphene (cis), which can cause estrogenic and mood-related side effects.
Can Clomiphene cause gyno or high estrogen?
Yes – by increasing LH and testosterone, aromatization to estradiol can increase, especially if you are estrogen-sensitive. Aromatase inhibitors may be used alongside.
Is Clomiphene safer than TRT?
It can be, particularly for men wishing to preserve fertility and testicular function, but long-term use should be monitored.
How long until I see results?
Most users report improved libido, mood, and energy in 2–4 weeks, with full hormonal restoration by 6–8 weeks.
🔍 Summary
Clomiphene is a versatile SERM that boosts natural testosterone, supports fertility, and restores HPG axis function. While effective, its mixed-isomer structure may cause mood swings and visual disturbances in some users. For long-term or sensitive individuals, Enclomiphene is a cleaner, more targeted alternative. Nonetheless, Clomiphene remains a go-to compound for hormonal recovery, PCT, and fertility protocols in both men and women.
Disclaimer: This content is for informational use only and does not constitute medical advice.
Sourcing
These are our vetted and trusted sources for high-quality research compounds chosen for their reliability, purity, and consistency. Shop smart, source safely.
USA & Canada
Unchained Compounds [Click Me]
Discount Code: UNCHAINED10
Discount Code: TB10
Discount Code: ROYALSAVE10
Europe
AVAILABLE SOON!
AUSTRALIA
AVAILABLE SOON!