🧬Ligandrol
Overview
Ligandrol, also known as LGD-4033, is a potent, non-steroidal Selective Androgen Receptor Modulator (SARM) developed to treat muscle wasting, osteoporosis, and age-related degeneration. As one of the most studied SARMs, Ligandrol is highly effective at increasing lean body mass, enhancing strength, and improving bone density—with fewer androgenic side effects than traditional anabolic steroids. It is widely used in bodybuilding, fitness, and post-injury recovery protocols.
📂 Category
Hormonal Modulators
Selective Androgen Receptor Modulators (SARMs)
🔬 Molecular Profile
Chemical Name: 4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Molecular Formula: C₁₄H₁₂F₆N₂O
Molecular Weight: ~338.24 g/mol
Class: Non-steroidal SARM
Half-Life: ~24–36 hours
Binding Affinity: Strong, selective agonist of androgen receptors in muscle and bone tissue
📌 What Is Ligandrol?
Name: LGD-4033 / Ligandrol
Type: Selective Androgen Receptor Modulator (SARM)
Function: Promotes muscle growth, increases bone mineral density, and improves recovery
Use: Utilized in performance enhancement, rehabilitation, and body recomposition protocols
🧪 Mechanism of Action
Ligandrol works by selectively activating androgen receptors (ARs) in skeletal muscle and bone, triggering:
Anabolic activity in muscle tissue (↑ protein synthesis & hypertrophy)
Bone strengthening through increased mineral density
Minimal activity in reproductive organs or sebaceous glands, reducing risk of hair loss, acne, or prostate issues
No aromatization to estrogen, preserving a clean hormonal profile
🩺 Most Common Uses
⚕️ Potential Benefits
Anabolic Muscle Support
Rapid lean muscle mass increase (up to 5–10 lbs in 8 weeks)
Increases strength and muscle endurance
Improves recovery and reduces fatigue during high-volume training
Bone & Joint Health
Supports bone mineral density
May assist in post-fracture or surgery recovery
Potential therapeutic use in osteopenia/osteoporosis
Performance & Fat Loss
Enhances metabolic output and nutrient partitioning
Helps maintain muscle fullness and vascularity during cutting phases
No water retention or bloating
💉 Administration & Dosage
Delivery Forms
Oral capsules or liquid – common research or fitness use format
Common Dosage Guidelines
📚 Scientific Research
Lean Mass Increase: Phase I clinical trial showed dose-dependent lean mass gains with no serious adverse effects
Muscle Wasting: Investigated as a treatment for cancer cachexia and sarcopenia
Bone Health: Preclinical models showed increased bone strength and density
Hormonal Profile: Mild to moderate testosterone suppression observed at higher doses in clinical trials
Ligandrol is one of the few SARMs with published human clinical trial data, supporting its safety and efficacy profile.
⚠️ Safety & Side Effects
Common Side Effects
Testosterone suppression (dose-dependent)
Mild fatigue, headaches, or irritability
Rare: acne, libido changes, or water retention
Estrogenic Side Effects
Does not aromatize, so estrogen-related issues (gyno, bloating) are rare
However, estradiol may rise indirectly due to elevated testosterone prior to suppression
PCT Consideration
A 4–6 week PCT is recommended post-cycle (e.g., Enclomiphene, Nolvadex, Clomid)
Bloodwork pre- and post-cycle is highly advised
📜 Legal & Regulatory Status
FDA Status: Investigational; not approved for human consumption
WADA Status: Prohibited in all competitive sports
Legal Availability: Sold by research chemical suppliers only; not a legal dietary supplement
❓ FAQ
Is Ligandrol a steroid?
No – Ligandrol is a non-steroidal SARM that binds selectively to androgen receptors without converting to DHT or estrogen.
How does it compare to RAD-140?
Ligandrol is slightly milder than RAD-140 in terms of suppression but still delivers strong anabolic results with less aggression.
Does Ligandrol need PCT?
Yes – at standard doses (10+ mg), natural testosterone may be suppressed, requiring PCT for hormonal recovery.
Can I stack Ligandrol with other SARMs or peptides?
Yes – common stacks include Cardarine (for endurance), MK-677 (GH stimulation), or Enclomiphene (for PCT and T support).
🔍 Summary
Ligandrol (LGD-4033) is a highly effective SARM that offers clean, potent muscle-building benefits with fewer side effects than anabolic steroids. Backed by clinical trials, it has become a top-tier compound for those seeking lean mass, strength, and recovery—whether bulking, cutting, or recovering from injury. When properly cycled and paired with PCT, Ligandrol remains a cornerstone compound in modern physique and performance enhancement.
Disclaimer: This content is for informational use only and does not constitute medical advice.
Sourcing
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