🧬 MK-677 (Ibutamoren)
Overview
MK-677, also known as Ibutamoren Mesylate, is a non-peptide, orally active growth hormone secretagogue. It mimics the action of ghrelin, a hunger hormone, and stimulates the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Unlike traditional peptides that require injections, MK-677 offers a convenient oral route and is known for boosting muscle mass, fat loss, recovery, and sleep—making it a favorite in bodybuilding, anti-aging, and biohacking circles.
📂 Category
Non-Peptide GH Secretagogue for Muscle Growth, Recovery, and Anti-Aging
🔬 Molecular Profile
Chemical Name: MK-677 (Ibutamoren Mesylate)
Molecular Formula: C₂₇H₃₆N₄O₅S
Molecular Weight: ~528.66 g/mol
Structure: Orally bioavailable non-peptide that acts as a ghrelin receptor agonist
📌 What Is MK-677?
Name: MK-677 (Ibutamoren)
Type: Non-peptide GH secretagogue
Function: Stimulates natural release of growth hormone and IGF-1 by binding to ghrelin receptors
Use: Supports muscle growth, fat metabolism, recovery, anti-aging, and sleep quality
🧪 Mechanism of Action
MK-677 activates the ghrelin receptor (GHS-R1a) to initiate powerful endogenous GH release:
Increases GH and IGF-1 levels significantly, mimicking natural pulses
Promotes anabolism (muscle-building) and lipolysis (fat-burning)
Improves REM and deep sleep, boosting GH levels during rest
No suppression of endogenous GH after discontinuation
Orally bioavailable, eliminating need for injections
🩺 Most Common Uses
⚕️ Potential Benefits
Physique & Performance
Increases lean muscle mass and strength
Reduces body fat, particularly abdominal and visceral fat
Enhances vascularity and muscle fullness
Hormonal & Metabolic
Elevates GH and IGF-1 to youthful levels
Promotes better insulin sensitivity and nutrient partitioning
May support bone density and joint integrity
Recovery & Longevity
Speeds up injury recovery and muscle repair
Enhances deep sleep and sleep quality
Supports skin elasticity and hair growth
💉 Administration & Dosage
Delivery Forms
Oral capsule or tablet – most popular GH secretagogue that doesn’t require injection
Typical Research Dosages
📚 Scientific Research
MK-677 has been studied in both healthy adults and clinical populations:
GH/IGF-1 Boost: Clinical trials show 50–100% increase in IGF-1 and GH within weeks
Muscle Growth: A 12-month study showed significant increases in lean body mass in older adults
Sleep Improvement: Enhanced REM and deep sleep with improved sleep architecture
Fat Metabolism: Shown to reduce visceral fat, especially in growth hormone-deficient individuals
Bone Density: Improved bone mineral density in longer-term studies
⚠️ Safety & Side Effects
Common Side Effects (Anecdotal & Clinical)
Increased appetite
Mild water retention or bloating
Numbness or tingling (GH-related)
Joint stiffness (transient)
Potential insulin resistance with high doses or long-term use
Monitoring Suggested
Fasting glucose / insulin sensitivity
IGF-1 levels to track GH response
Water retention or weight spikes in first 2–4 weeks
📜 Legal & Regulatory Status
FDA Status: Investigational; not approved for any medical condition
Classification: Research compound
Legality: Available for research; not legal for human consumption in many regions
WADA Status: Banned in professional sports due to GH-stimulating effects
❓ FAQ
Is MK-677 the same as HGH?
No – MK-677 stimulates your own GH production, unlike synthetic HGH which replaces it.
Can it be stacked with peptides?
Yes – MK-677 pairs well with CJC-1295 (no DAC), Ipamorelin, BPC-157, and TB-500 for advanced recovery and growth protocols.
Will I lose gains after stopping it?
Some water retention may subside, but muscle and fat loss improvements are often retained if diet and training continue.
Can it be used long-term?
Yes – but it's recommended to monitor blood sugar, IGF-1, and take breaks after 12–16 week cycles if necessary.
🔍 Summary
MK-677 (Ibutamoren) is a powerful oral GH secretagogue that offers a convenient, injection-free method to boost growth hormone, IGF-1, muscle mass, and sleep quality. Its broad range of benefits—from fat loss to anti-aging—makes it a go-to for those seeking hormonal optimization and performance enhancement without synthetic hormones or daily injections.
Disclaimer: This content is for informational use only and does not constitute medical advice.
Sourcing
These are our vetted and trusted sources for high-quality research compounds chosen for their reliability, purity, and consistency. Shop smart, source safely.
USA & Canada
Unchained Compounds [Click Me]
Discount Code: UNCHAINED10
Discount Code: TB10
Discount Code: ROYALSAVE10
Europe
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AUSTRALIA
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