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🧬 PT-141 (Bremelanotide)

Overview

PT-141, also known as Bremelanotide, is a synthetic melanocortin receptor agonist used to enhance libido, sexual arousal, and performance in both men and women. Originally derived from the tanning peptide Melanotan II, PT-141 selectively activates melanocortin receptors involved in sexual desire—not skin pigmentation. It is FDA-approved for treating female sexual interest/arousal disorder (FSIAD) and is widely used off-label for erectile dysfunction, libido enhancement, and sexual performance support.

📂 Category

Neuropeptide for Libido, Sexual Arousal, and Erectile Support

🔬 Molecular Profile

Chemical Name: Bremelanotide
Peptide Class: Melanocortin receptor agonist
Molecular Formula: C₅₀H₆₈N₁₄O₁₀
Molecular Weight: ~1025.2 g/mol
Structure: Synthetic analog of α-MSH (alpha-melanocyte-stimulating hormone), targeting MC3R and MC4R receptors

📌 What Is PT-141?

Name: PT-141 / Bremelanotide
Type: Melanocortin receptor agonist
Function: Increases sexual desire and arousal by activating central nervous system receptors
Use: Approved for female sexual dysfunction, used off-label for ED, libido support, and sexual performance

🧪 Mechanism of Action

Unlike PDE5 inhibitors like Viagra, PT-141 works through the brain, not the vascular system:

Stimulates MC3R and MC4R receptors in the hypothalamus
Enhances sexual desire, motivation, and arousal signals
Does not require sexual stimulation to initiate arousal response
Has minimal effect on blood pressure, making it safer for some patients than PDE5 inhibitors

🩺 Most Common Uses

⚕️ Potential Benefits

Sexual Function

Boosts libido and arousal in men and women
Improves erectile firmness and responsiveness
Enhances pleasure, confidence, and sexual satisfaction

Psychological Support

Acts on the brain's sexual reward center
Helpful for performance anxiety, psychological ED, and libido suppression from SSRIs
May support mood and motivation via melanocortin signaling

Female-Specific Benefits

One of the few compounds approved for women’s sexual health
Increases mental readiness and physical receptivity
Especially helpful in perimenopause, postpartum, and antidepressant-induced low libido

💉 Administration & Dosage

Delivery Forms

Injectable (Subcutaneous) – most common and effective form
Nasal Spray – available in some compounded or research versions

Typical Dosage Guidelines

📚 Scientific Research

FDA Approval (Women): Approved in 2019 as Vyleesi® for premenopausal women with HSDD
ED Research (Men): Improved erectile function and sexual satisfaction in men with psychogenic and mixed ED
Neuroendocrine Data: Demonstrated central action on melanocortin receptors, impacting sexual motivation and pleasure
Brain Imaging Studies: Increased activation in reward and arousal regions of the brain post-administration

⚠️ Safety & Side Effects

Common Side Effects

Nausea (up to 40%) – dose-dependent, often mild
Facial flushing or warmth
Temporary headache
Rare: increased blood pressure or injection site irritation

Precautions

Not recommended for patients with uncontrolled hypertension
Avoid using with nitrates or vasodilators
Avoid multiple doses in 24 hours due to potential overstimulation or nausea

📜 Legal & Regulatory Status

FDA-Approved: Yes, as Vyleesi® (1.75 mg injection) for female sexual dysfunction
Off-Label Use: Widely used in men’s sexual health clinics
Availability: Legal with prescription; also available in compounded and research formats

❓ FAQ

How is PT-141 different from Viagra or Cialis?
PT-141 works through the brain, not the vascular system, making it ideal for libido and arousal, rather than purely mechanical erections.

Does PT-141 work for women?
Yes – it is FDA-approved for female sexual dysfunction (Vyleesi) and has strong evidence for improving desire and arousal.

How fast does it work?
Most users feel effects in 30–60 minutes, with a peak around 1–2 hours and lingering benefits up to 12 hours.

Can I stack PT-141 with other peptides or supplements?
Yes – often paired with testosterone therapy, Oxytocin, or HCG for synergistic libido and hormonal support.

🔍 Summary

PT-141 (Bremelanotide) is a revolutionary libido-enhancing peptide that works on the brain’s arousal and reward centers to improve sexual desire, function, and satisfaction. With applications for both men and women, and minimal side effects compared to traditional ED drugs, PT-141 is a go-to solution for those seeking confidence, connection, and restored intimacy.

Disclaimer: This content is for informational use only and does not constitute medical advice.

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