• Chemical Name: 2-chloro-4-[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]benzonitrile

• Molecular Formula: C₂₀H₁₆ClN₅O₂

• Molecular Weight: ~393.8 g/mol

• Class: SARM (non-steroidal)

• Half-Life: ~16–20 hours

• Binding Affinity: High affinity for androgen receptors in muscle and bone, minimal in prostate

• Name: RAD-140 (Testolone)

• Type: Selective Androgen Receptor Modulator (SARM)

• Function: Mimics the anabolic effects of testosterone without strong androgenic side effects

• Use: Promotes muscle gain, strength, fat loss, and neuroprotection

• Status: Investigational compound, not FDA-approved but widely used in research and fitness communities

• Protein synthesis and muscle hypertrophy

• Bone density improvements

• Fat oxidation and metabolism

• Neuroprotective gene expression (shown to reduce β-amyloid buildup in preclinical studies)

• Minimal activation of androgen receptors in the prostate, skin, or liver, reducing typical steroidal side effects

• Builds dry, lean muscle mass quickly

• Increases strength, endurance, and muscle fullness

• Enhances vascularity and definition in cutting phases

• Testosterone-like effects without converting to estrogen or DHT

• Supports libido, mood, and confidence in low-testosterone states

• Potential neuroprotective properties via androgen receptor modulation in the brain

• Oral liquid or capsule – standard research and fitness formats

• No need for injections due to long half-life and oral bioavailability

• Oral liquid or capsule – standard research and fitness formats

• No need for injections due to long half-life and oral bioavailability

• Muscle Anabolism: Animal studies showed superior lean mass gains with minimal prostate growth

• Neuroprotection: Reduced neuronal cell death and β-amyloid toxicity in models of cognitive decline

• Bone Density: Demonstrated improvement in mineral content and strength in osteoporosis research

• Anabolic/Androgenic Ratio: Estimated to be >90:1, far exceeding testosterone

While not FDA-approved, RAD-140 is being evaluated for muscle wasting, breast cancer, and age-related degeneration.

• Testosterone suppression (dose-dependent)

• Mild aggression or irritability in some users

• Temporary hair shedding or acne in androgen-sensitive individuals

• Elevated liver enzymes in rare cases (especially with long cycles or stacking)

• RAD-140 does not aromatize to estrogen, but increased testosterone can raise estradiol indirectly

• Rare cases of gyno if stacked with aromatizing compounds or in high doses

• Suggested 4-week PCT with Enclomiphene, Nolvadex, or Clomid

• Bloodwork recommended before, during, and after cycle

• FDA Status: Investigational drug – not approved for human consumption

• Research Use: Legal to purchase for research in most countries

• WADA Status: Banned in all competitive sports

• Supplement Status: Not legally sold as a dietary supplement, but available from research vendors