• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro

• Molecular Formula: C₃₃H₅₇N₁₁O₉

• Molecular Weight: ~751.88 g/mol

• Structure: Synthetic analog of tuftsin, modified to enhance stability and cross the blood-brain barrier

• Name: Selank (also known as TP-7)

• Type: Synthetic anxiolytic and neuropeptide

• Function: Reduces anxiety, boosts cognition, modulates immune response, enhances neuroplasticity

• Use: Commonly used in stress management, cognitive optimization, and mood regulation therapies

• Enhances GABAergic signaling → Calms the nervous system and reduces anxiety

• Increases BDNF expression → Supports neuroplasticity and learning

• Regulates monoamines → Balances serotonin, dopamine, and norepinephrine

• Modulates immune system → Enhances antiviral defense and reduces neuroinflammation

• Reduces cortisol → Lowers the biological response to chronic stress

• Reduces social anxiety, generalized anxiety, and nervous tension

• Supports clear thinking and alertness without overstimulation

• Enhances memory consolidation and retrieval

• Protects neurons from oxidative and inflammatory stress

• Increases BDNF and supports neurogenesis

• May be beneficial in ADHD, PTSD, and mild cognitive impairment

• Improves resistance to viral infections

• Regulates immune cytokine balance

• May support autoimmune modulation (under research)

• Intranasal spray – most common and effective form

• Injectable – used less frequently in clinical settings

• Sublingual (rare) – lower bioavailability

• Anxiolytic Effects: Comparable to benzodiazepines, but without sedation, withdrawal, or addiction

• Cognition Studies: Improved mental performance and learning in both healthy adults and patients with cognitive decline

• Immunomodulation: Enhanced interferon activity, increased resistance to influenza viruses

• Neurochemical Studies: Increased levels of GABA, dopamine, and BDNF in animal and human models

Selank has been approved in Russia for clinical use and is often prescribed for anxiety, PTSD, and mental fatigue.

• Mild nasal irritation (rare)

• Slight dizziness in sensitive users (temporary)

• No sedation, withdrawal, or dependency observed

• Non-toxic even at high doses

• Safe for long-term use

• No known drug interactions

• Russia/Eastern Europe: Approved for medical use

• United States & Western Countries: Not FDA-approved; available as a research compound or nootropic supplement

• Legality: Legal to possess for personal research; often used off-label in wellness clinics