๐งฌ TB-500 Peptide
Overview
TB-500 is the synthetic version of a naturally occurring peptide known as Thymosin Beta-4, found in virtually all human and animal cells. Renowned for its potent tissue-repairing and regenerative properties, TB-500 plays a critical role in cell migration, inflammation reduction, and tissue remodeling, making it popular in sports medicine, veterinary care, and performance enhancement circles.
๐ Category
Peptide with Regenerative, Anti-inflammatory, and Angiogenic Properties
๐ฌ Molecular Profile
Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys
Molecular Weight: ~4963.49 g/mol
Molecular Formula: CโโโHโโ โNโ โOโโS
Origin: Synthetic version of a peptide segment of Thymosin Beta-4
๐ What Is TB-500?
Name: TB-500 (Thymosin Beta-4 Fragment)
Type: Synthetic peptide fragment
Function: Promotes wound healing, muscle regeneration, and anti-inflammatory effects
Usage: Primarily research-based; widely used in athletic recovery, equine therapy, and regenerative support
๐งช Mechanism of Action
TB-500 exhibits powerful systemic healing effects through several mechanisms:
Actin Binding: Regulates cell cytoskeleton via G-actin binding, crucial for cell movement and tissue growth
Angiogenesis: Stimulates formation of new blood vessels, increasing oxygenation and nutrient delivery
Anti-inflammatory Activity: Downregulates inflammatory cytokines and promotes immune modulation
Stem Cell Activation: Mobilizes and recruits stem cells to sites of injury for faster repair
Tissue Remodeling: Facilitates structural repair in muscle, tendon, ligament, and skin
๐ฉบ Most Common Uses
โ๏ธ Potential Benefits
Physical Healing
Accelerates healing of tendons, ligaments, and muscles
Improves mobility and flexibility post-injury
Speeds up post-surgical recovery
Anti-inflammatory Action
Reduces inflammation in joints, muscles, and connective tissue
May assist in managing autoimmune-related soft tissue inflammation
Cardiac and Organ Repair
Shown to aid in heart muscle regeneration in animal models
Enhances vascular growth and blood flow to damaged organs
๐ Administration & Dosage
Delivery Forms
Injectable (Subcutaneous or Intramuscular) โ most effective route
Typical Research Dosages
๐ Scientific Research
Although most TB-500 studies are preclinical (animal-based), the findings are compelling:
Muscle Injury: Accelerated muscle fiber regeneration and reduced fibrosis
Cardiac Healing: Regenerated heart tissue after ischemic injury in mice
Ocular Repair: Enhanced corneal wound healing
Skin Recovery: Faster epithelialization and reduced scarring
Human trials are limited, and most applications are based on extrapolated preclinical data.
โ ๏ธ Safety & Side Effects
Commonly Reported (Anecdotal)
Mild fatigue or lethargy
Temporary redness/swelling at injection site
Rare: Headaches or dizziness
Toxicology
Animal studies show no significant toxicity at commonly used dosages
No mutagenic or carcinogenic activity reported in current data
๐ Legal & Regulatory Status
FDA Status: Not approved for human use
Classification: Research Chemical
Availability: Sold for veterinary or research purposes only.
โ FAQ
How is TB-500 different from Thymosin Beta-4 (Tฮฒ4)?
TB-500 is a synthetic shorter peptide fragment of the larger Tฮฒ4 molecule, designed to retain the key healing effects while being more stable and cost-effective.
Is TB-500 legal to use?
It is legal for research, but not approved for medical or therapeutic use in humans.
Can TB-500 be used long-term?
While many report using it for maintenance dosing, long-term safety in humans has not been established.
Does TB-500 need to be cycled?
Yes, typical cycles last 4โ6 weeks, followed by periodic maintenance doses if needed.
๐ Summary
TB-500 is a powerful regenerative peptide used in research and veterinary medicine for its impressive healing and anti-inflammatory capabilities. Whether for injuries, post-surgery recovery, or chronic inflammation, its role in cellular repair and angiogenesis makes it a valuable asset in the peptide toolkit.
Disclaimer: This information is for educational purposes only and does not constitute medical advice.
Sourcing
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